Neurophysiology of Basal Ganglia
and Regulation by Cannabinoids
We investigate these questions by performing electrophysiological recordings of the activity of neuronal ensemble in freely moving rodents. Behavioral tasks aimed at clarifying this complex brain-body relationship are used. A special emphasis is put on capturing the dynamic of movements during those tasks with high temporal and spatial resolutions.
Our goal is to further the understanding of the relation between the kinematic of locomotion (speed and gait) and the activity of population of neurons in the hippocampus and the basal ganglia. The word ¨relation¨ is used here because in such brain areas, neuronal activity is both controlling and influenced by the ongoing locomotor activity. Understanding this bidirectional dialogue between brain and body is maybe what defines best our investigations.
To go beyond correlative measurements, we additionally use pharmacological and behavioral tricks (like compounds that target the cannabinoid receptors) and study their impact on both neuronal activity and behavioral performances.
David Robbe
David Robbe
DAvid Robbe